BK virus (BKV) quantification in urine samples of bone marrow transplanted patients is helpful for diagnosis of hemorrhagic cystitis, although wide individual variations exist.

@article{Priftakis2003BKV,
  title={BK virus (BKV) quantification in urine samples of bone marrow transplanted patients is helpful for diagnosis of hemorrhagic cystitis, although wide individual variations exist.},
  author={Peter Priftakis and Gordana Bogdanovi{\'c} and Parviz Kokhaei and H{\aa}kan Mellstedt and Tina Dalianis},
  journal={Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology},
  year={2003},
  volume={26 1},
  pages={71-7}
}
BACKGROUND Hemorrhagic cystitis (HC) in allogeneic bone marrow transplanted (BMT) patients is associated with BK virus (BKV) reactivation manifested as BK viruria. However, since 77-90% of all adult BMT patients excrete BKV, viral reactivation alone cannot be responsible for HC. Recently, a significant overrepresentation of C-->G mutations in the Sp1 binding site in the non-coding control region (NCCR) of BKV was shown to be present in HC patients and absent in non-HC patients. OBJECTIVES We… CONTINUE READING