BK virus: Current understanding of pathogenicity and clinical disease in transplantation

@article{Chong2019BKVC,
  title={BK virus: Current understanding of pathogenicity and clinical disease in transplantation},
  author={Stephanie Chong and Michelle Antoni and Andrew Macdonald and Matthew B. Reeves and Mark Harber and Ciara Magee},
  journal={Reviews in Medical Virology},
  year={2019},
  volume={29}
}
BK polyomavirus (BKV) is an important cause of graft loss in renal transplant recipients that continues to pose a significant challenge to clinicians due to its frequently unpredictable onset, persistence, and the lack of effective antiviral agents or prevention strategies. This review covers our current understanding of epidemiology, viral transmission and disease progression, and treatment and prevention strategies that have been used to manage this disease. 

BK Virus Nephropathy in Kidney Transplantation: A State-of-the-Art Review

In this in-depth state-of-the-art review, the history of the virus, virology, epidemiology, cellular response, pathogenesis, methods of screening and diagnosis, evidence-based treatment strategies, and upcoming therapeutics are discussed, along with the issue of re-transplantation in patients.

Pre-Transplantation Assessment of BK Virus Serostatus: Significance, Current Methods, and Obstacles

The different BK PyV VP1 antigens types used for detection are reviewed and the various BKPyV serostatus assay techniques’ advantages and disadvantages are considered.

BK Polyomavirus Hijacks Extracellular Vesicles for En Bloc Transmission

A new mechanism is shown that can be released into EVs, enabling viral particles to infect cells using an alternative entry pathway, and likely plays a critical role during the primary infection and in the persistence, but also the reactivation, of BKPyV.

Pathogenicity of BK virus on the urinary system

Introduction The polyomaviruses are omnipresent in nature. The major sites of BK virus appearance are the kidney tubular epithelial cells and urinary bladder surface transitional cells. Material and

Implementing a regional standardized BK polyomavirus screening protocol across eleven transplant centres

Adherence to the protocol for BKPyV screening for kidney transplants performed in calendar years 2016–2017 was low with 54% at 12 months and 38% at 24 months, reflecting challenges of managing transplant patients at all centres.

Post-allogeneic hematopoietic stem cell transplantation viral reactivations and viremias: a focused review on human herpesvirus-6, BK virus and adenovirus

The outcomes of patients with these viremias remain unsatisfactory and even long-term survivors experience increased morbidity, so some patients develop significant morbidity and may not need therapy at all and some of the antiviral therapies used are potentially toxic.

BK virus nephropathy in a heart transplant recipient

It is recommended that the BK virus be considered as a cause of renal dysfunction in heart transplant recipients, with the aim of detecting its replication in time to reduce immunosuppressive therapy before irreversible compromise of renal function may manifest.

A Nomogram for Predicting BK Virus Activation in Kidney Transplantation Recipients Using Clinical Risk Factors

Results showed that patients with BK virus active infection were associated with a deceased donor, had lower direct bilirubin levels, a higher proportion of albumin in serum protein electrophoresis, and lower red blood cells and neutrophil counts.

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