BK large conductance Ca²+-activated K+ channel-deficient mice are not resistant to hypotension and display reduced survival benefit following polymicrobial sepsis.

@article{OBrien2011BKLC,
  title={BK large conductance Ca²+-activated K+ channel-deficient mice are not resistant to hypotension and display reduced survival benefit following polymicrobial sepsis.},
  author={Alastair J O'Brien and Deepti Terala and Nelson N Orie and Nathan A. Davies and Parjam S. Zolfaghari and Mervyn Singer and Lucie H Clapp},
  journal={Shock},
  year={2011},
  volume={35 5},
  pages={485-91}
}
Nitric oxide-mediated activation of large conductance calcium-activated potassium (BK) channels is considered an important underlying mechanism of sepsis-induced hypotension. Indeed, the nonselective K-channel inhibitor, tetraethylammonium chloride (TEA), has been proposed as a potential treatment to raise blood pressure in septic shock by virtue of its ability to inhibit BK channels. As experimental evidence has so far relied on pharmacological inhibition, we examined the effects of channel… CONTINUE READING

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Following slurry , BKα and WT mice developed similar degrees of hypotension over 10 h with no difference in cardiac output as assessed by echocardiography between groups .
Following slurry , BKα and WT mice developed similar degrees of hypotension over 10 h with no difference in cardiac output as assessed by echocardiography between groups .
As experimental evidence has so far relied on pharmacological inhibition , we examined the effects of channel deletion using BKα subunit knockout ( α , Slo ) mice in two mouse models of polymicrobial sepsis , namely , intraperitoneal fecal slurry and cecal ligation and puncture .
However , following cecal ligation and puncture , a significantly reduced survival was seen in both BKα mice and ( high - dose ) TEA - treated WT mice compared with untreated WT animals .
As experimental evidence has so far relied on pharmacological inhibition , we examined the effects of channel deletion using BKα subunit knockout ( α , Slo ) mice in two mouse models of polymicrobial sepsis , namely , intraperitoneal fecal slurry and cecal ligation and puncture .
However , following cecal ligation and puncture , a significantly reduced survival was seen in both BKα mice and ( high - dose ) TEA - treated WT mice compared with untreated WT animals .
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