BK channels play a counter-adaptive role in drug tolerance and dependence.

Abstract

Disturbance of neural activity by sedative drugs has been proposed to trigger a homeostatic response that resists unfavorable changes in net cellular excitability, leading to tolerance and dependence. The Drosophila slo gene encodes a BK-type Ca(2+)-activated K(+) channel implicated in functional tolerance to alcohol and volatile anesthetics. We… (More)
DOI: 10.1073/pnas.1005439107

Topics

5 Figures and Tables

Cite this paper

@article{Ghezzi2010BKCP, title={BK channels play a counter-adaptive role in drug tolerance and dependence.}, author={Alfredo Ghezzi and Jascha B. Pohl and Yan Wang and Nigel S. Atkinson}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2010}, volume={107 37}, pages={16360-5} }