BK channel subunit composition modulates molecular tolerance to ethanol.

@article{FeinbergZadek2008BKCS,
  title={BK channel subunit composition modulates molecular tolerance to ethanol.},
  author={Paula Leslie Feinberg-Zadek and Gilles E Martin and Steven N. Treistman},
  journal={Alcoholism, clinical and experimental research},
  year={2008},
  volume={32 7},
  pages={
          1207-16
        }
}
BACKGROUND The large conductance calcium-activated potassium channel (also called BK channel or Slo channels) is a well-studied target of alcohol action, and plays an important role in behavioral tolerance. METHODS Using patch clamp electrophysiology, we examined human BK channels expressed in HEK293 cells to test whether tolerance to ethanol occurs in excised patches and whether it is influenced by subunit composition. Three combinations were examined: hSlo, hSlo + beta(1), and hSlo + beta(4… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 12 CITATIONS