BK Polyomavirus Replication in Renal Tubular Epithelial Cells Is Inhibited by Sirolimus, but Activated by Tacrolimus Through a Pathway Involving FKBP‐12

Abstract

BK polyomavirus (BKPyV) replication causes nephropathy and premature kidney transplant failure. Insufficient BKPyV-specific T cell control is regarded as a key mechanism, but direct effects of immunosuppressive drugs on BKPyV replication might play an additional role. We compared the effects of mammalian target of rapamycin (mTOR)- and calcineurin… (More)
DOI: 10.1111/ajt.13541

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@inproceedings{Hirsch2016BKPR, title={BK Polyomavirus Replication in Renal Tubular Epithelial Cells Is Inhibited by Sirolimus, but Activated by Tacrolimus Through a Pathway Involving FKBP‐12}, author={H. Hirsch and K. Yakhontova and M. Lu and Jan D Manzetti}, booktitle={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons}, year={2016} }