BK Channels Mediate Cholinergic Inhibition of High Frequency Cochlear Hair Cells

@inproceedings{Wersinger2010BKCM,
  title={BK Channels Mediate Cholinergic Inhibition of High Frequency Cochlear Hair Cells},
  author={Eric Wersinger and Will J. McLean and Paul Albert Fuchs and Sonja J Pyott},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND Outer hair cells are the specialized sensory cells that empower the mammalian hearing organ, the cochlea, with its remarkable sensitivity and frequency selectivity. Sound-evoked receptor potentials in outer hair cells are shaped by both voltage-gated K(+) channels that control the membrane potential and also ligand-gated K(+) channels involved in the cholinergic efferent modulation of the membrane potential. The objectives of this study were to investigate the tonotopic contribution… CONTINUE READING