BIX01294 suppresses osteoclast differentiation on mouse macrophage-like Raw264.7 cells.

@article{Tsuda2013BIX01294SO,
  title={BIX01294 suppresses osteoclast differentiation on mouse macrophage-like Raw264.7 cells.},
  author={Hiromasa Tsuda and Ning Zhao and Kenichi Imai and Kuniyasu Ochiai and Pishan Yang and Naoto Suzuki},
  journal={Bosnian journal of basic medical sciences},
  year={2013},
  volume={13 4},
  pages={
          271-5
        }
}
Gene expressionis controlled by epigenetic mechanisms including histone methylation. Osteoclasts are bone-resorptive cells that differentiate from hematopoietic-precursor cells by receptor activator of nuclear factor-κB ligand (RANKL) stimulation. Although BIX01294, a specific inhibitor of G9a, which works as a histone H3 lysine 9 (H3K9) methyltransferase, reportedly changes cellular differentiational stage, its effect on osteoclast differentiation is unclear. In this study, the effects of… CONTINUE READING
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