BIRC6/Apollon gene expression in childhood acute leukemia: impact on therapeutic response and prognosis.

@article{Ismail2012BIRC6ApollonGE,
  title={BIRC6/Apollon gene expression in childhood acute leukemia: impact on therapeutic response and prognosis.},
  author={Eman Abdel Rahman Ismail and Hanan Mohamed Mahmoud and Lamis Mohamed Tawfik and Deena Mohamed Habashy and Amira Adly and Nayera Hazaa El-Sherif and Mahmoud Ahmed Abdelwahab},
  journal={European journal of haematology},
  year={2012},
  volume={88 2},
  pages={118-27}
}
OBJECTIVE Although BIRC6/Apollon seems to play a critical role as an antiapoptotic regulator, its clinical relevance in acute leukemia remains largely elusive. Therefore, we aimed to investigate BIRC6 gene expression in childhood acute leukemia in relation to clinicopathological characteristics at presentation, therapeutic response, and prognosis. METHODS BIRC6 expression level was assessed in 75 children with acute leukemia; 30 patients with acute myeloblastic leukemia (AML) and 45 patients… CONTINUE READING

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