• Corpus ID: 8405066

BIOLOGICAL PSYCHIATRY IN PRESS THE BORDERLINE DIAGNOSIS III: IDENTIFYING ENDOPHENOTYPES FOR GENETIC STUDIES Running Title: ENDOPHENOTYPES/GENETICS OF BORDERLINE PERSONALITY

@inproceedings{Torgersen2002BIOLOGICALPI,
  title={BIOLOGICAL PSYCHIATRY IN PRESS THE BORDERLINE DIAGNOSIS III: IDENTIFYING ENDOPHENOTYPES FOR GENETIC STUDIES Running Title: ENDOPHENOTYPES/GENETICS OF BORDERLINE PERSONALITY},
  author={Svenn Torgersen and John G. Gunderson and W. John Livesley and Kenneth S. Kendler},
  year={2002}
}
While it is generally acknowledged that borderline personality disorder has a complex, multifactoral etiology with interacting genetic and environmental substrates, the specific genetic underpinnings of this disorder have not been extensively investigated. Family aggregation studies suggest the heritability for borderline personality disorder as a diagnosis, but the genetic basis for this disorder may be stronger for dimensions such as impulsive/aggression and affective instability than for the… 

References

SHOWING 1-10 OF 59 REFERENCES
A twin study of personality disorders.
TLDR
PDs seem to be more strongly influenced by genetic effects than almost any axis I disorder, and more than most broad personality dimensions, but there is a large variation in heritability among the different PDs, probably partly because of a moderate sample size and low prevalence of the specific disorders.
Genetics of patients with borderline personality disorder.
  • S. Torgersen
  • Psychology
    The Psychiatric clinics of North America
  • 2000
Genetic and nosological aspects of schizotypal and borderline personality disorders. A twin study.
TLDR
Investigation of the co-twins indicated that genetic factors seemed to influence the development of the schizotypal, but not the borderline, personality disorders, and the basic genetic core of theschizotypals seemed to consist of schizoid and paranoidlike features, and not psychoticlike cognitive and perceptual distortions.
Psychiatric genetics: search for phenotypes
Affective and impulsive personality disorder traits in the relatives of patients with borderline personality disorder.
TLDR
Familial transmission of the hallmark borderline-related personality characteristics are suggested and the possibility that these familial traits may be partially independent is raised.
DSM-III Disorders in the Families of Borderline Outpatients
The family history of 48 outpatients meeting both DIB and DSM-III criteria for borderline personality disorder (BPD), 29 outpatients meeting DSM-III criteria for antisocial personality disorder
"True" schizotypal personality disorder: a study of co-twins and relatives of schizophrenic probands.
TLDR
The present study suggests that DSM-III-R schizotypal disorder is defined by a set of criteria that partly describe a "true" schizophrenia-related personality disorder and partly features that are not specific for relatives of schizophrenic probands.
The validity of DSM-III borderline personality disorder. A phenomenologic, family history, treatment response, and long-term follow-up study.
To test the validity of the DSM-III diagnosis of borderline personality disorder (BPD), we examined the phenomenology, family history, treatment response, and four-to-seven-year long-term outcome of
Familial transmission of DSM-III borderline personality disorder.
TLDR
The relatives of the borderline patients did not have a higher morbid risk for treated mania or schizophrenia than that usually reported for the population at large, and the relative of a borderline patient was about ten times more likely to have been treated for a borderline or borderlinelike personality disorder.
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