BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Pages 734-740 FRUCTOSE PREVENTS 1 -METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRtDINE (MPTP)- INDUCED ATP DEPLETION AND TOXICITY IN ISOLATED HEPATOCYTES

Abstract

The loss of v iab i l i t y of isolated rat hepatocytes exposed to either l -me thy l -4 pheny ] -1 ,2 ,3 ,6 t e t r ahyd ropy r i d i ne (MPTP) or i t s t ox i c metabot i te l m e t h y l 4 phenytpyridinium ion (MPP +) was prevented by addition of fructose to the incubation medium. This protection was dependent on fructose concentration, being complete at… (More)

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4 Figures and Tables