Corpus ID: 98840512

BIOAVAILABILITY OF DIPYRONE DROPS IN MAN

@inproceedings{An1995BIOAVAILABILITYOD,
  title={BIOAVAILABILITY OF DIPYRONE DROPS IN MAN},
  author={Wan An},
  year={1995}
}
  • Wan An
  • Published 1995
  • Chemistry
  • The bioavailabilities of dipyrone drops and dipyrone tablets were compared in humanbody following crossover oral administration of single 1 g doses to 6 healthy subjects. High-performance liquid chromatography was used to determine the active metabolite, 4-monomethylaminoantipyrine (MAA) in plasma . The peak time of MAA in plasma (Tp) was 1.08±0. 25h (drops ) and 1.36 ± 0. 13h (tablets), P0. 05 respectively . The relative bioavailablilty (F = AUC drops/AUC tablet ) was 1.26 ± 0.44, P0. 05. 

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