BINDING OF 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN (TCDD), 3-METHYLCHOLANTHRE. (MC), AND BENZO(A)PYRENE (BP) TO MOLYBDATE STABLIZED HUMAN PLACENTAL Ah RECEPTOR

Abstract

Induction of human cytochrome P1-450 by environmental pollutants is variable and may affect toxicity of many xenobiotics. This response to chemical exposures is genetically regulated in humans, but the mechanisms are poorly understood. In animals, a specific protein, the Ah receptor, regulates P1-450 induction by substrate binding and nuclear interactions… (More)
DOI: 10.1203/00006450-198704010-00427

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