BIK, the founding member of the BH3-only family proteins: mechanisms of cell death and role in cancer and pathogenic processes

@article{Chinnadurai2008BIKTF,
  title={BIK, the founding member of the BH3-only family proteins: mechanisms of cell death and role in cancer and pathogenic processes},
  author={G. Chinnadurai and S. Vijayalingam and Ramachandran Rashmi},
  journal={Oncogene},
  year={2008},
  volume={27},
  pages={S20-S29}
}
BIK is the founding member of the BH3-only family pro-apoptotic proteins. BIK is predominantly localized in the ER and induces apoptosis through the mitochondrial pathway by mobilizing calcium from the ER to the mitochondria and remodeling the mitochondrial cristae. BIK-mediated apoptosis is mediated by selective activation of BAX. BIK also induces non-apoptotic cell death in certain cell types by unknown mechanisms. BIK is non-essential for animal development, but appears to be functionally… CONTINUE READING

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