BID regulation by p53 contributes to chemosensitivity

@article{Sax2002BIDRB,
  title={BID regulation by p53 contributes to chemosensitivity},
  author={Joanna K. Sax and Peiwen Fei and Maureen E Murphy and Eric Bernhard and S Stanley J. Korsmeyer and Wafik S El-Deiry},
  journal={Nature Cell Biology},
  year={2002},
  volume={4},
  pages={842-849}
}
The role of the p53 protein (encoded by TP53) in tumour suppression relies partly on the ability of p53 to regulate the transcription of genes that are important in cell-cycle arrest and in apoptosis. But the apoptotic pathway mediated by p53 is not fully understood. Here we show that BID, a member of the pro-apoptotic Bcl-2 family of proteins, is regulated by p53. BID mRNA is increased in a p53-dependent manner in vitro and in vivo, with strong expression in the splenic red pulp and colonic… CONTINUE READING
Highly Influential
This paper has highly influenced 13 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
143 Citations
54 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 143 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 54 references

Regulations, Functions and Medicinal Applications Vol

  • S. Kadkol, J. Juang, Wu, T. C. in Tumor Suppressor Genes
  • 2 (ed. El-Deiry, W. S.)
  • 2003

the cell’s response to p53

  • K. H. Vousden, Lu, X. Live or let die
  • Nature Rev. Cancer 2, 594–604
  • 2002

Similar Papers

Loading similar papers…