BID regulation by p53 contributes to chemosensitivity

  title={BID regulation by p53 contributes to chemosensitivity},
  author={Joanna K. Sax and Peiwen Fei and Maureen E Murphy and Eric Bernhard and S Stanley J. Korsmeyer and Wafik S El-Deiry},
  journal={Nature Cell Biology},
The role of the p53 protein (encoded by TP53) in tumour suppression relies partly on the ability of p53 to regulate the transcription of genes that are important in cell-cycle arrest and in apoptosis. But the apoptotic pathway mediated by p53 is not fully understood. Here we show that BID, a member of the pro-apoptotic Bcl-2 family of proteins, is regulated by p53. BID mRNA is increased in a p53-dependent manner in vitro and in vivo, with strong expression in the splenic red pulp and colonic… CONTINUE READING
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