BI 6727 and GSK461364 suppress growth and radiosensitize osteosarcoma cells, but show limited cytotoxic effects when combined with conventional treatments.

@article{Bogado2015BI6A,
  title={BI 6727 and GSK461364 suppress growth and radiosensitize osteosarcoma cells, but show limited cytotoxic effects when combined with conventional treatments.},
  author={Rodrigo F E Bogado and Julia A Pezuk and Harley Francisco de Oliveira and Luiz Gonzaga Tone and Mar{\'i}a Sol Brassesco},
  journal={Anti-cancer drugs},
  year={2015},
  volume={26 1},
  pages={56-63}
}
Polo-like kinase 1 (PLK1), a key regulator of mitosis, is often overexpressed in childhood cancers and is associated with poor prognosis. Previous reports have shown that inhibition of PLK1 might serve as a promising anticancer treatment for osteosarcoma. In this study, we tested the second-generation PLK1 inhibitors BI 6727 and GSK461364 in HOS and MG-63… CONTINUE READING