BI-2 destabilizes HIV-1 cores during infection and Prevents Binding of CPSF6 to the HIV-1 Capsid

@article{Fricke2014BI2DH,
  title={BI-2 destabilizes HIV-1 cores during infection and Prevents Binding of CPSF6 to the HIV-1 Capsid},
  author={Thomas Fricke and Cindy Buffone and Silvana Opp and Jos{\'e} Carlos Valle-Casuso and Felipe Diaz-Griffero},
  journal={Retrovirology},
  year={2014},
  volume={11}
}
BackgroundThe recently discovered small-molecule BI-2 potently blocks HIV-1 infection. BI-2 binds to the N-terminal domain of HIV-1 capsid. BI-2 utilizes the same capsid pocket used by the small molecule PF74. Although both drugs bind to the same pocket, it has been proposed that BI-2 uses a different mechanism to block HIV-1 infection when compared to PF74.FindingsThis work demonstrates that BI-2 destabilizes the HIV-1 core during infection, and prevents the binding of the cellular factor… 

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