BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stress.

  title={BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stress.},
  author={Han-Jung Chae and Hyung-ryong Kim and Chunyan Xu and B{\'e}atrice Bailly-Ma{\^i}tre and Maryla Krajewska and Stan Stanislaw Krajewski and Steven Banares and Janice Cui and Murat H Digicaylioglu and Ning Ke and Shinichi Kitada and Edward Z Monosov and M. I. Thomas and Christina L. Kress and Jeremy R Babendure and Roger Tsien and Stuart Lipton and John C. Reed},
  journal={Molecular cell},
  volume={15 3},
Bax inhibitor-1 (BI-1) is an evolutionarily conserved endoplasmic reticulum (ER) protein that suppresses cell death in both animal and plant cells. We characterized mice in which the bi-1 gene was ablated. Cells from BI-1-deficient mice, including fibroblasts, hepatocytes, and neurons, display selective hypersensitivity to apoptosis induced by ER stress agents (thapsigargin, tunicamycin, brefeldin A), but not to stimulators of mitochondrial or TNF/Fas-death receptor apoptosis pathways… CONTINUE READING
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