BHRF1 exerts an antiapoptotic effect and cell cycle arrest via Bcl-2 in murine hybridomas.

@article{Milin2015BHRF1EA,
  title={BHRF1 exerts an antiapoptotic effect and cell cycle arrest via Bcl-2 in murine hybridomas.},
  author={Ernest Mili{\'a}n and Eva Prats and Jordi Joan Cair{\'o} and Francesc G{\`o}dia and Joaquim Vives},
  journal={Journal of biotechnology},
  year={2015},
  volume={209},
  pages={58-67}
}
Apoptosis has been widely studied in order to find methods to increase the life-span and production performance in large-scale animal cell cultures. The use of anti-apoptotic genes has emerged as an efficient method to reduce apoptosis in a variety of biotechnological relevant cell lines, including CHO and hybridomas, alternatively to small molecule inhibitors. It is already known that expression of BHRF1, an Epstein-Barr virus-encoded early protein homologous to the anti-apoptotic protein Bcl… CONTINUE READING

Citations

Publications citing this paper.

References

Publications referenced by this paper.
Showing 1-10 of 49 references

heterologous viral infection

P. Theodorakis, C. D’sa-Eipper, T. Subramanian
Unmasking • 1996
View 5 Excerpts
Highly Influenced

“ Johns Hopkins , Baltimore , MD 21205 , USA and NIH / NINDS , Bethesda , MD 20892 , USA . ”

J. M. Hardwick, R. J. Youle
2009
View 1 Excerpt

Bcl-2 inhibitors: small

M. Vogler, D. Dinsdale, M.J.S. Dyer, G. M. Cohen
2008
View 1 Excerpt

Similar Papers

Loading similar papers…