BHMT G742A and MTHFD1 G1958A polymorphisms and Down syndrome risk in the Brazilian population.

@article{Zampieri2012BHMTGA,
  title={BHMT G742A and MTHFD1 G1958A polymorphisms and Down syndrome risk in the Brazilian population.},
  author={Bruna Lancia Zampieri and Joice Matos Biselli and Eny Maria Goloni-Bertollo and {\'E}rika Cristina Pavarino},
  journal={Genetic testing and molecular biomarkers},
  year={2012},
  volume={16 6},
  pages={628-31}
}
BACKGROUND Mechanisms underlying meiotic nondisjunction are poorly understood. Attempts to elucidate the causes of Down syndrome (DS) have analyzed the relationship between polymorphism in folate metabolism and DS. AIM The role of methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) G1958A and betaine-homocysteine methyltransferase (BHMT) G742A polymorphisms in DS risk was investigated. METHODS Blood samples were collected from a total of 86 DS mothers and from 161 control mothers. The… CONTINUE READING

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ternal gene polymorphisms involved in folate metabolism as risk factors for Down syndrome offspring in Southern Brazil

  • AP Brandalize, E Bandinelli, PA DosSantos
  • Dis Markers
  • 2010
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