BHLHB4 is a bHLH transcriptional regulator in pancreas and brain that marks the dimesencephalic boundary.

@article{Bramblett2002BHLHB4IA,
  title={BHLHB4 is a bHLH transcriptional regulator in pancreas and brain that marks the dimesencephalic boundary.},
  author={Debra E. Bramblett and Neal G. Copeland and Nancy A. Jenkins and Ming-jer Tsai},
  journal={Genomics},
  year={2002},
  volume={79 3},
  pages={402-12}
}
We have cloned a basic helix-loop-helix (bHLH) factor gene, Bhlhb4, from a mouse beta-cell line. Fluorescence in situ hybridization (FISH) and genetic mapping place Bhlhb4 at the telomeric end of mouse chromosome 2 (H3-H4), syntenic to human chromosome 20q13. Based on phylogenetic analysis, BHLHB4 belongs to a new subgroup of bHLH factors including at least four previously identified mouse bHLH factors: BHLHB5, MIST1, OLIG1, OLIG2, and OLIG3. In the developing nervous system, Bhlhb4 was found… CONTINUE READING

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