BHK cells transfected with NCX3 are more resistant to hypoxia followed by reoxygenation than those transfected with NCX1 and NCX2: Possible relationship with mitochondrial membrane potential.

@article{Secondo2007BHKCT,
  title={BHK cells transfected with NCX3 are more resistant to hypoxia followed by reoxygenation than those transfected with NCX1 and NCX2: Possible relationship with mitochondrial membrane potential.},
  author={Agnese Secondo and Rosaria Ilaria Staiano and Antonella Scorziello and Rossana Sirabella and Francesca Boscia and Annagrazia Adornetto and Valeria Valsecchi and Pasquale Molinaro and Lorella Maria Teresa Canzoniero and Gianfranco F Di Renzo and Lucio Annunziato},
  journal={Cell calcium},
  year={2007},
  volume={42 6},
  pages={521-35}
}
The specific role played by NCX1, NCX2, and NCX3, the three isoforms of the Na+/Ca2+ exchanger (NCX), has been explored during hypoxic conditions in BHK cells stably transfected with each of these isoforms. Six major findings emerged from the present study: (1) all the three isoforms were highly expressed on the plasma membranes of BHK cells; (2) under physiological conditions, the three NCX isoforms showed similar functional activity; (3) hypoxia plus reoxygenation induced a lower increase of… CONTINUE READING
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