BH3 peptidomimetics potently activate apoptosis and demonstrate single agent efficacy in neuroblastoma

@article{Goldsmith2006BH3PP,
  title={BH3 peptidomimetics potently activate apoptosis and demonstrate single agent efficacy in neuroblastoma},
  author={Kelly C. Goldsmith and Xi Liu and Vincent Q Dam and Brian T Morgan and Mayadah Shabbout and Avital Cnaan and Anthony Letai and S Stanley J. Korsmeyer and Michael D. Hogarty},
  journal={Oncogene},
  year={2006},
  volume={25},
  pages={4525-4533}
}
The major impediment to cure for many malignancies is the development of therapy resistance with resultant tumor progression. Genetic alterations leading to subversion of inherent apoptosis pathways are common themes in therapy resistance. Bcl-2 family proteins play a critical role in regulating mitochondrial apoptosis that governs chemotherapeutic effects… CONTINUE READING