BH3-only proteins in cell death initiation, malignant disease and anticancer therapy

  title={BH3-only proteins in cell death initiation, malignant disease and anticancer therapy},
  author={Verena Labi and Miriam Erlacher and Stephan Kiessling and Andreas Villunger},
  journal={Cell Death and Differentiation},
Induction of apoptosis in tumour cells, either by direct activation of the death receptor pathway using agonistic antibodies or recombinant ligands, or direct triggering of the Bcl-2-regulated intrinsic apoptosis pathway by small molecule drugs, carries high hopes to overcome the shortcomings of current anticancer therapies. The latter therapy concept builds on a more detailed understanding of how Bcl-2-like molecules maintain mitochondrial integrity and how BH3-only proteins and Bax/Bak-like… CONTINUE READING
82 Citations
136 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 82 extracted citations


Publications referenced by this paper.
Showing 1-10 of 136 references

Loss of the tissue-specific proapoptoptic BH3only protein Nbk/Bik is a unifying feature of renal cell carcinoma

  • IS CSturm, B Gillissen, +6 authors PT Daniel
  • Cell Death Differ
  • 2006
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…