BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α.

@article{Rodrguez2012BH3onlyPA,
  title={BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α.},
  author={Diego Andr{\'e}s Rodr{\'i}guez and S. Zamorano and Fernanda Lisbona and Diego Rojas-Rivera and Hery Urra and Juan R Cubillos-Ruiz and Ricardo Armis{\'e}n and Daniel R Henr{\'i}quez and Emily H-Y Cheng and Michal Letek and Tom{\'a}{\vs} Vaisar and Thergiory Irrazabal and Christian Gonz{\'a}lez-Billault and Anthony Letai and Felipe X. Pimentel-Mui{\~n}os and Guido Kroemer and Claudio Hetz},
  journal={The EMBO journal},
  year={2012},
  volume={31 10},
  pages={
          2322-35
        }
}
Adaptation to endoplasmic reticulum (ER) stress depends on the activation of the unfolded protein response (UPR) stress sensor inositol-requiring enzyme 1α (IRE1α), which functions as an endoribonuclease that splices the mRNA of the transcription factor XBP-1 (X-box-binding protein-1). Through a global proteomic approach we identified the BCL-2 family member PUMA as a novel IRE1α interactor. Immun oprecipitation experiments confirmed this interaction and further detected the association of IRE1… CONTINUE READING
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