BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo.

@article{Erlacher2005BH3onlyPP,
  title={BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo.},
  author={Miriam Erlacher and Ewa M Michalak and Priscilla Kelly and Verena Labi and Harald Niederegger and Leigh Coultas and Jerry M. Adams and Andreas Strasser and Andreas Villunger},
  journal={Blood},
  year={2005},
  volume={106 13},
  pages={4131-8}
}
Numerous p53 target genes have been implicated in DNA damage-induced apoptosis signaling, but proapoptotic Bcl-2 (B-cell leukemia 2) family members of the BH3 (Bcl-2 homolog region [BH] 3)-only subgroup appear to play the critical initiating role. In various types of cultured cells, 3 BH3-only proteins, namely Puma (p53 up-regulated modulator of apoptosis), Noxa, and Bim (Bcl-2 interacting mediator of cell death), have been shown to initiate p53-dependent as well as p53-independent apoptosis in… CONTINUE READING
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BH3-only Bcl-2 family member Bim is required for apoptosis Puma AND Bim MEDIATE ANTICANCER THERAPY EFFECTS

  • P Bouillet, JF Purton, DI Godfrey
  • BLOOD,
  • 2005

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