• Corpus ID: 60083106

BH3-only proteinsによる神経細胞死制御

  title={BH3-only proteinsによる神経細胞死制御},
  author={和中 明生},
The carboxyl-terminal sequence of Bim enables Bax activation and killing of unprimed cells
Examination of additional point mutants unexpectedly revealed that the CTS of Bim is required for physiological concentrations of BIM to activate Bax and that different residues in the C TS enable Bax activation and binding to membranes.
The pro-death role of autophagy and apoptosis in cell death induced by the BH3 mimetic gossypol
The results suggest that apoptotic cell death is induced by gossypol in DKO MEFs, whereas autophagy plays a death-promoting role in gOSSypol-mediated death of WT MEFs cells.
n‐butylidenephthalide treatment prolongs life span and attenuates motor neuron loss in SOD1G93A mouse model of amyotrophic lateral sclerosis
To evaluate the therapeutic effects of n‐butylidenephthalide (BP) in SOD1G93A mouse model of amyotrophic lateral sclerosis and explore the possible mechanisms, a new drug called BP is introduced into the model.
Regulation of stressed-induced cell death by the Bcl-2 family of apoptotic proteins
Heat-induced apoptosis is a model system for studying the consequences of protein misfolding and is mediated by the Bcl-2 family of proteins, which consists of both pro-APoptotic and anti-apoptotic members that control mitochondrial integrity.
Benzo(a)pyrene Induced p53 Mediated Male Germ Cell Apoptosis: Synergistic Protective Effects of Curcumin and Resveratrol
It is concluded that curcumin-resveratrol synergistically modulated MAPKs and p53, prevented oxidative stress, regulated the expression of pro and anti-apoptotic proteins as well as the proteins involved in B(a)P metabolism thus protected germ cells from B( a)P induced apoptosis.
Commutation ou extinction de l'expression du BCR et impact sur la cellule B
Lors de la reconnaissance de leur antigene specifique, les lymphocytes B vont s’activer et interagir avec les autres cellules des organes lymphoides secondaires (cellules folliculaires dendritiques,
Can Cancer Therapy be Achieved by Bridging Apoptosis and Autophagy: a Method Based on microRNA-Dependent Gene Therapy and Phytochemical Targets.
This review covers roles of microRNAs and chemopreventive agents and makes an attempt at outlining possible partnerships in maximizing cancer cell death with minimal normal cell damage.
T cell-specific inhibition of multiple apoptotic pathways blocks negative selection and causes autoimmunity
It is reported that T cell-specific expression of a Bcl2 BH3 mutant transgene results in enhanced rescue of thymocytes from negative selection, providing strong evidence that negative selection is crucial for establishing T cell tolerance.
Anti-apoptotic BCL-2 family proteins in acute neural injury
It is discussed that several anti-apoptotic BCL-2 proteins influence mitochondrial bioenergetics and control neuronal Ca2+ homeostasis independent of their classical role in cell death signaling.