BH3 mimetics to improve cancer therapy; mechanisms and examples.

@article{Zhang2007BH3MT,
  title={BH3 mimetics to improve cancer therapy; mechanisms and examples.},
  author={Lin Zhang and Lihua Ming and Jian Ning Yu},
  journal={Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy},
  year={2007},
  volume={10 6},
  pages={207-17}
}
Tumor cell survival is highly dependent on the expression of certain pro-survival Bcl-2 family proteins. An attractive therapeutic approach is to inhibit these proteins using agents that mimic the Bcl-2 homology 3 (BH3) domains of the proapoptotic Bcl-2 family members, which neutralize these proteins by binding to their surface hydrophobic grooves. A number of BH3 mimetic peptides and small molecules have been described, a few of which have advanced into clinical trials. Recent studies have… CONTINUE READING

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