BH3 domains define selective inhibitory interactions with BHRF-1 and KSHV BCL-2

@article{Flanagan2008BH3DD,
  title={BH3 domains define selective inhibitory interactions with BHRF-1 and KSHV BCL-2},
  author={Adrienne Margaret Flanagan and Anthony Letai},
  journal={Cell Death and Differentiation},
  year={2008},
  volume={15},
  pages={580-588}
}
The Epstein–Barr and Kaposi's sarcoma γ-herpesviruses (KSHVs) are associated with certain cancers, and encode B-cell leukemia/lymphoma 2 (BCL-2) homologs, BHRF-1 and KSHV BCL-2, respectively. Little is known, however, about the molecular interactions allowing viral BCL-2 homologs to mediate their anti-apoptotic function. Cellular anti-apoptotic proteins, such as BCL-2 and MCL-1, prevent death via selective interactions with pro-death BH3-only proteins. To investigate whether BHRF-1 and KSHV BCL… CONTINUE READING