BH3 Profiling Reveals Selectivity by Herpesviruses for Specific Bcl-2 Proteins To Mediate Survival of Latently Infected Cells.

Abstract

Herpesviruses, including human cytomegalovirus (HCMV), Epstein-Barr virus (EBV), and Kaposi's sarcoma-associated herpesvirus, establish latency by modulating or mimicking antiapoptotic Bcl-2 proteins to promote survival of carrier cells. BH3 profiling, which assesses the contribution of Bcl-2 proteins towards cellular survival, was able to globally… (More)
DOI: 10.1128/JVI.00236-15

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@article{Cojohari2015BH3PR, title={BH3 Profiling Reveals Selectivity by Herpesviruses for Specific Bcl-2 Proteins To Mediate Survival of Latently Infected Cells.}, author={Olesea Cojohari and Christine M Burrer and Megan A Peppenelli and Fardokht A. Abulwerdi and Z. Nikolovska-Coleska and Gary C Chan}, journal={Journal of virology}, year={2015}, volume={89 10}, pages={5739-46} }