BH3 Peptides Induce Mitochondrial Fission and Cell Death Independent of BAX/BAK

Abstract

BH3 only proteins trigger cell death by interacting with pro- and anti-apoptotic members of the BCL-2 family of proteins. Here we report that BH3 peptides corresponding to the death domain of BH3-only proteins, which bind all the pro-survival BCL-2 family proteins, induce cell death in the absence of BAX and BAK. The BH3 peptides did not cause the release… (More)
DOI: 10.1371/journal.pone.0005646

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