BFAST: An Alignment Tool for Large Scale Genome Resequencing

  title={BFAST: An Alignment Tool for Large Scale Genome Resequencing},
  author={Nils Homer and Barry Merriman and Stanley F. Nelson},
  booktitle={PloS one},
BACKGROUND The new generation of massively parallel DNA sequencers, combined with the challenge of whole human genome resequencing, result in the need for rapid and accurate alignment of billions of short DNA sequence reads to a large reference genome. Speed is obviously of great importance, but equally important is maintaining alignment accuracy of short reads, in the 25-100 base range, in the presence of errors and true biological variation. METHODOLOGY We introduce a new algorithm… CONTINUE READING
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