BET protein Brd4 activates transcription in neurons and BET inhibitor Jq1 blocks memory in mice

@inproceedings{Korb2015BETPB,
  title={BET protein Brd4 activates transcription in neurons and BET inhibitor Jq1 blocks memory in mice},
  author={Erica Korb and Margo Herre and Ilana Zucker-Scharff and Robert B Darnell and C David Allis},
  booktitle={Nature Neuroscience},
  year={2015}
}
Precise regulation of transcription is crucial for the cellular mechanisms underlying memory formation. However, the link between neuronal stimulation and the proteins that directly interact with histone modifications to activate transcription in neurons remains unclear. Brd4 is a member of the bromodomain and extra-terminal domain (BET) protein family, which binds acetylated histones and is a critical regulator of transcription in many cell types, including transcription in response to… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 19 times over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 39 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 51 references

Similar Papers

Loading similar papers…