BET bromodomain inhibition triggers apoptosis of NF1-associated malignant peripheral nerve sheath tumors through Bim induction.

@article{Patel2014BETBI,
  title={BET bromodomain inhibition triggers apoptosis of NF1-associated malignant peripheral nerve sheath tumors through Bim induction.},
  author={Amish J. Patel and C. L. Liao and Zhiguo Chen and Chiachi Liu and Yong Xin Wang and Lu Q. Le},
  journal={Cell reports},
  year={2014},
  volume={6 1},
  pages={81-92}
}
Malignant peripheral nerve sheath tumors (MPNSTs) are highly aggressive sarcomas that develop sporadically or in neurofibromatosis type 1 (NF1) patients. There is no effective treatment for MPNSTs and they are typically fatal. To gain insights into MPNST pathogenesis, we utilized an MPNST mouse model that allowed us to study the evolution of these tumors at the transcriptome level. Strikingly, in MPNSTs we found upregulation of a chromatin regulator, Brd4, and show that BRD4 inhibition… CONTINUE READING
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