BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment.

@article{Winter2017BETBP,
  title={BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment.},
  author={Georg E Winter and Andreas Mayer and Dennis L. Buckley and Michael A Erb and Justine E. Roderick and Sarah Vittori and Jaime M. Reyes and Julia di Iulio and Amanda L. Souza and Christopher J. Ott and Justin M Roberts and Rhamy Zeid and Thomas G. Scott and Joshiawa Paulk and Kate Lachance and Calla M. Olson and Shiva Dastjerdi and Sophie Bauer and Charles Y. Lin and Nathanael S Gray and Michelle A Kelliher and L Stirling Churchman and James E. Bradner},
  journal={Molecular cell},
  year={2017},
  volume={67 1},
  pages={
          5-18.e19
        }
}
Processive elongation of RNA Polymerase II from a proximal promoter paused state is a rate-limiting event in human gene control. A small number of regulatory factors influence transcription elongation on a global scale. Prior research using small-molecule BET bromodomain inhibitors, such as JQ1, linked BRD4 to context-specific elongation at a limited number of genes associated with massive enhancer regions. Here, the mechanistic characterization of an optimized chemical degrader of BET… CONTINUE READING