BET 1: Does a normal D-dimer rule out cerebral venous sinus thrombosis (CVST)?

@article{Smith2018BET1D,
  title={BET 1: Does a normal D-dimer rule out cerebral venous sinus thrombosis (CVST)?},
  author={Emma Smith and Varun Kumar},
  journal={Emergency Medicine Journal},
  year={2018},
  volume={35},
  pages={396 - 397}
}
A 32-year-old woman presented to the emergency department (ED) with a history of occipital headache and intermittent blurred vision for the past 3 weeks. D-dimer performed on admission is within normal range. Can you safely rule out cerebral venous sinus thrombosis (CVST)? In (patients presenting to and ED with suspected CVST) does a (normal D-dimer) rule out this condition? NICE Healthcare interface Medline 1966–November 2016 [ddimer.ti,ab] AND [exp INTRACRANIAL EMBOLISM/OR exp INTRACRANIAL… 
5 Citations

Cerebral venous thrombosis: a practical guide

TLDR
Current knowledge on the risk factors, diagnosis, treatment and prognosis of CVT in adults, and highlights some areas for future research is summarised.

Cerebral venous thrombosis: a practical guide.

TLDR
Current knowledge on the risk factors, diagnosis, treatment and prognosis of CVT in adults, and highlights some areas for future research is summarised.

The diagnostic utility of unenhanced computed tomography of the brain and D-dimer levels in acute cerebral venous sinus thrombosis: A quantitative study

TLDR
Hounsfield blood density and its normalized ratio with hematocrit are positively correlated with D-dimer levels, which may indicate active blood coagulation in a cerebral venous sinus and unenhanced CT of the brain can be a valuable objective diagnostic tool for acute CVST diagnosis.

Efficacy of intravascular mechanical thrombectomy combined with thrombolysis and anticoagulant therapy in the treatment of cerebral venous sinus thrombosis and its effect on neurological function and coagulation indices.

TLDR
Intravascular mechanical thrombectomy plus thrombolysis combined with AT for patients with CVST is effective, which can effectively improve the coagulation function and promote the recovery of neurological function, with fewer complications and a good prognosis.

References

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D-dimer for the exclusion of cerebral venous thrombosis: a meta-analysis of low risk patients with isolated headache

TLDR
D-dimers have a high negative predictive value in patients with isolated headache for excluding CVT, comparable to the values accepted in PE and DVT.

D‐dimer testing in the diagnosis of cerebral vein thrombosis: a systematic review and a meta‐analysis of the literature

TLDR
The findings suggest that D‐dimer may be a useful diagnostic tool in the management of patients with suspected CVT, as calculated with a bivariate random‐effects regression approach.

D-dimers (DD) in CVST

TLDR
D-dimer is elevated in patients with acute/subacute CVST as reported in studies on D-dimers (DD) as well as number of venous sinuses involvement and risk factors.