BEN: a novel domain in chromatin factors and DNA viral proteins

  title={BEN: a novel domain in chromatin factors and DNA viral proteins},
  author={Saraswathi Abhiman and Lakshminarayan M. Iyer and L. Aravind},
  volume={24 4},
We report a previously uncharacterized alpha-helical module, the BEN domain, in diverse animal proteins such as BANP/SMAR1, NAC1 and the Drosophila mod(mdg4) isoform C, in the chordopoxvirus virosomal protein E5R and in several proteins of polydnaviruses. Contextual analysis suggests that the BEN domain mediates protein-DNA and protein-protein interactions during chromatin organization and transcription. The presence of BEN domains in a poxviral early virosomal protein and in polydnaviral… CONTINUE READING

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