BEK and FLG, two receptors to members of the FGF family, are amplified in subsets of human breast cancers.

@article{Adnane1991BEKAF,
  title={BEK and FLG, two receptors to members of the FGF family, are amplified in subsets of human breast cancers.},
  author={Jalila Adnane and Patrick Gaudray and Craig A Dionne and Gregg Crumley and Michael Jaye and Joseph Schlessinger and P. Jeanteur and Daniel Birnbaum and Charles Theillet},
  journal={Oncogene},
  year={1991},
  volume={6 4},
  pages={659-63}
}
Tumor DNA samples from 387 breast carcinomas have been investigated for amplification of BEK and FLG genes, both of which have been shown to code for cell surface receptors to FGFs. BEK and FLG were found amplified in 11.5 and 12.7% of breast tumors respectively. Statistical analysis, performed on the subset of 297 primary cancers without presurgical therapy, showed for BEK a trend of preferential amplification in patients above 50 years (P = 0.055), whereas amplification of FLG could… CONTINUE READING

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