author={Berend Olivier and Jan Mos and D Rasmussen},
  journal={Drug Metabolism and Drug Interactions},
  pages={31 - 84}
In this paper the effects of serenics (eltoprazine and fluprazine) are described in several animal models for offensive agonistic, defensive agonistic and predatory behaviour. They are compared with the effects of a number of other putative anti-aggressive compounds or drugs used clinically in order to ameliorate aggressive behaviour of psychiatric patients. In isolation-induced offensive aggression in mice, eltoprazine has a marked and potent anti-aggressive activity, although numerous other… 

Figures and Tables from this paper

Further pharmacological characterization of eltoprazine: focus on its anxiolytic, anorexic, and adverse‑effect potential.

Effects of eltoprazine in different anxiety tests were equivocal while its effect on body weight seems robust and requires further investigation, to be determined whether these effects can be expected at the doses free of adverse effects.

Chronic treatment with eltoprazine does not lead to tolerance in its anti-aggressive action, in contrast to haloperidol

Papel de la serotonina en la conducta agresiva

The purpose of this work was to collect and integrate the information available from different studies on the involvement of the serotonin (5-HT) in the modulation of aggressive behavior, and application of agonists/antagonist selective for certain subtype receptors seems a more promising approach to unraveling the role of 5-HT in aggression.

reuptake inhibitors in isolated aggressive mice

The b-adrenoceptor antagonist, metoprolol, but not the a -adrenoing antagonist, prazosin, facilitated the anti aggressive effect of citalopram, and the significance of these findings is discussed relative to the above hypothesis.

Behavioral and pharmacogenetics of aggressive behavior.

There are receptor populations in specific brain regions that preferentially modulate specific types of aggression and specific receptor subpopulations for GABA, glutamate and neuropeptides as they modulate the canonical aminergic neurotransmitters in brainstem, limbic and cortical regions with the ultimate outcome of attenuating or escalating aggressive behavior.

Pharmacokinetic evaluation of eltoprazine

An overview of the pharmacokinetics (PK) of the non-stimulant medication eltoprazine is provided and endophenotypical characteristics may be provided to help identify specific subgroups of patients with ADHD, who can benefit from the development of el toprazine, to maximize efficacy while minimizing adverse reactions.

Serotonergic receptors in anxiety and aggression; evidence from animal pharmacology

Mixed 5‐HT1A,1B agonists appear specific antiaggressive agents, reducing offence without sedative or other unwanted side‐effects, in preclinical models of anxiety and aggression in rodents.

Aggression, anxiety and vocalizations in animals: GABAA and 5-HT anxiolytics

Ethological studies of vocal expressions in rodents and primates during social confrontations, separation from social companions, or exposure to aversive environmental events are proposed as promising sources of information on the affective features of behavior.

New psychotropic drug remedies for the future

An overview of new forms of psychotropic drug therapy that may be expected to play a role in psychiatric practice in the 1990s is presented and the types of newly designed agents and treatment strategies currently under investigation are outlined.



Serenics and aggression

The behavioural effects of a new class of psychotropic drugs, the serenics, which exert specific antiaggressive effects in animal paradigms of (offensive) agonistic behaviour are described.

Psychopharmacology of Aggression in Humans

This chapter reviews studies on the pharmacology of aggression published over the past two to three years and suggests that cholinergic and catecholaminergic mechanisms are involved in the induction and enhancement of predatory or instrumental aggression while serotonergic and gamma amino butyric acid-ergic mechanisms is inhibitory.

Pharmaco-Ethological Analysis of Social Behaviour of Isolated Mice

Pro-Aggressive Actions of Benzodiazepines

The benzodiazepines (BDZ) are known for a wide variety of pharmacological effects, among which anxiolytic, hypnotic, sedatory, muscle relaxing and anticonvulsant actions are the most prominent. Much

Ethopharmacological and Neuropharmacological Analyses of Agonistic Behaviour

Computerized ethological pharmacology applies specific ethological, mathematical, neuropharmacological and neurochemical principles to the analysis and control of agonistic behaviour. In recent years

Psychopharmacology of Aggression

This small volume, sponsored by the British Association for Psychopharmacology, consists of 17 chapters from departments of ethology, pharmacology, neurosurgery, psychology, and psychiatry, among


  • M. Kršiak
  • Biology, Psychology
    British journal of pharmacology
  • 1979
The inhibition of aggression induced by these drugs does not seem to be due to neuromuscular impairment and seems to this extent specific, and effects of the drugs on sociable activities in aggressive mice seem to correlate with their action on punished responding and other types of suppressed behaviour.

The pharmacology of isolation-induced aggressive behavior in mice.

  • J. Malick
  • Biology, Psychology
    Current developments in psychopharmacology
  • 1979
This review attempts to summarize the literature on the effects of drugs on isolation-induced aggression in mice and concludes that statements concerning drug selectivity or specificity are meaningless without some evidence for a lack of neurological impairment in isolated, aggressive mice.