BDNF val66met modulates the association between childhood trauma, cognitive and brain abnormalities in psychoses.

@article{Aas2013BDNFVM,
  title={BDNF val66met modulates the association between childhood trauma, cognitive and brain abnormalities in psychoses.},
  author={Monica Aas and Unn Kristin Haukvik and Srdjan Djurovic and \Orjan Bergmann and Lavinia Athanasiu and Martin S Tesli and Tone Hellvin and Nils Eiel Steen and Ingrid Agartz and Steinar Lorentzen and Kjetil S. Sundet and Ole A. Andreassen and Ingrid Melle},
  journal={Progress in neuro-psychopharmacology & biological psychiatry},
  year={2013},
  volume={46},
  pages={181-8}
}
OBJECTIVE Brain derived neurotrophic factor (BDNF) is important for brain development and plasticity, and here we tested if the functional BDNF val66met variant modulates the association between high levels of childhood abuse, cognitive function, and brain abnormalities in psychoses. METHOD 249 patients with a broad DSM-IV schizophrenia spectrum disorder or bipolar disorder were consecutively recruited to the TOP research study (mean±age: 30.7±10.9; gender: 49% males). History of childhood… CONTINUE READING
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