BDNF val66met influences time to onset of levodopa induced dyskinesia in Parkinson's disease.

@article{Foltynie2009BDNFVI,
  title={BDNF val66met influences time to onset of levodopa induced dyskinesia in Parkinson's disease.},
  author={Thomas Foltynie and Binith Joseph Cheeran and Caroline H. Williams-Gray and Mark J. J. Edwards and S. A. Schneider and Daniel Weinberger and John C. Rothwell and Roger A. Barker and Kailash P Bhatia},
  journal={Journal of neurology, neurosurgery, and psychiatry},
  year={2009},
  volume={80 2},
  pages={141-4}
}
BACKGROUND Levodopa induced dyskinesias (LID) are a common problem which ultimately limit the effective treatment of patients with Parkinson's disease (PD). There is accumulating evidence that LID develop due to abnormal synaptic plasticity, which is in turn influenced by the release of brain derived neurotrophic factor (BDNF). METHODS The influence of a common functional polymorphism of the BDNF gene on the risk of developing dyskinesias in a large cohort of patients with PD (n = 315), who… CONTINUE READING