BDNF signaling is necessary for the antidepressant-like effect of naringenin

  title={BDNF signaling is necessary for the antidepressant-like effect of naringenin},
  author={L. Yi and Bin-bin Liu and Jing Li and L. Luo and D. Wu},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  • L. Yi, Bin-bin Liu, +2 authors D. Wu
  • Published 2014
  • Psychology, Medicine
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • Previous studies in our laboratory have demonstrated that naringenin produced antidepressant-like action in tail suspension test (TST). However, the underlying mechanisms involved in neurotrophin system by which naringenin works have not been investigated. The present study extends earlier works on the role of brain-derived neurotrophic factor (BDNF) in regulating the antidepressant-like actions of naringenin in chronic unpredictable mild stress (CUMS). We showed that a 21-day regimen with… CONTINUE READING

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