BDNF signaling is necessary for the antidepressant-like effect of naringenin
@article{Yi2014BDNFSI, title={BDNF signaling is necessary for the antidepressant-like effect of naringenin}, author={Li-Tao Yi and Bin-Bin Liu and Jing Li and Liu Luo and Qing Liu and Di Geng and Yue Tang and Yuan Xia and Ding-ping Wu}, journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry}, year={2014}, volume={48}, pages={135-141} }
59 Citations
Schisandra chinensis produces the antidepressant-like effects in repeated corticosterone-induced mice via the BDNF/TrkB/CREB signaling pathway
- Biology, PsychologyPsychiatry Research
- 2016
Activation of hippocampal BDNF signaling is involved in the antidepressant-like effect of the NMDA receptor antagonist 7-chlorokynurenic acid
- Biology, PsychologyBrain Research
- 2016
Antidepressant-like effects of standardized gypenosides: involvement of brain-derived neurotrophic factor signaling in hippocampus
- Biology, PsychologyPsychopharmacology
- 2016
This study demonstrates that gypenosides exhibit antidepressant-like effects in mice, which may be mediated by activation of the BDNF-ERK/Akt signaling pathway in the hippocampus.
Roles of BDNF/TrkB Signaling Pathway in Anti-Depressant Effect of Vortioxetine
- Biology, Psychology
- 2018
Vortioxetine significantly shortened the immobility time of the depressive mice in forced swim test without affecting the locomotor activity of the mice in open fields, suggesting the antidepressant effect of against depression in mice.
Putative Role of Monoaminergic Systems in Antidepressant and Anxiolytic Effects of Naringin in Mice: An Interaction Study with Receptor Antagonists
- Biology, PsychologyJournal of Pharmaceutical Research International
- 2021
The findings suggest that the antidepressant-like activity exhibited by naringin might be mediated via interactions with 5-HTergic, noradrenergic, and dopaminergic receptors, while the anxiolytic effect might involve interaction with both 5- HTergic and noradreceptor receptors.
Macranthol promotes hippocampal neuronal proliferation in mice via BDNF-TrkB-PI3K/Akt signaling pathway.
- BiologyEuropean journal of pharmacology
- 2015
Brain‐derived Neurotrophic Factor Signaling Mediates the Antidepressant‐like Effect of the Total Flavonoids of Alpiniae Oxyphyllae Fructus in Chronic Unpredictable Mild Stress Mice
- Biology, PsychologyPhytotherapy research : PTR
- 2016
Results demonstrated that AOF might exert antidepressant‐like effects by targeting TrkB receptor‐mediated pERK/pCREB/BDNF signal systems, which could help to identify the AOF receptor.
Puerarin ameliorated the behavioral deficits induced by chronic stress in rats
- Biology, PsychologyScientific Reports
- 2017
Repeated administration of puerarin alleviated the behavioral deficits induced by chronic stress which was associated with the biosynthesis of neurosteroids, normalization of serotonergic system and preventing HPA axis dysfunction.
BDNF-ERK-CREB signalling mediates the role of miR-132 in the regulation of the effects of oleanolic acid in male mice.
- BiologyJournal of psychiatry & neuroscience : JPN
- 2014
Oleanolic acid induces the upregulation of miR-132, which serves as an important regulator of neurotrophic actions, mainly through the activation of the hippocampal BDNF-ERK-CREB signalling pathways.
Naringenin improves depressive- and anxiety-like behaviors in mice exposed to repeated hypoxic stress through modulation of oxido-inflammatory mediators and NF-kB/BDNF expressions
- Biology, PsychologyBrain Research Bulletin
- 2021
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