BDNF profoundly and specifically increases KCNQ4 expression in neurons derived from embryonic stem cells.

Abstract

Neurons resembling the spiral ganglion neurons (SGNs) of the auditory nerve can be generated from embryonic stem cells through induced overexpression of the transcription factor Neurogenin-1 (Neurog1). While recapitulating this developmental pathway produces glutamatergic, bipolar neurons reminiscent of SGNs, these neurons are functionally immature, being… (More)
DOI: 10.1016/j.scr.2012.08.005

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@article{Purcell2013BDNFPA, title={BDNF profoundly and specifically increases KCNQ4 expression in neurons derived from embryonic stem cells.}, author={Erin K. Purcell and Amy Yang and Liqian Liu and John Matthew Velkey and Marti M Morales and R. Duncan}, journal={Stem cell research}, year={2013}, volume={10 1}, pages={29-35} }