BDNF overexpression in mouse hippocampal astrocytes promotes local neurogenesis and elicits anxiolytic-like activities

@article{Quesseveur2013BDNFOI,
  title={BDNF overexpression in mouse hippocampal astrocytes promotes local neurogenesis and elicits anxiolytic-like activities},
  author={Ga{\"e}l Quesseveur and Denis J David and M C Gaillard and Patrick Pla and M V Wu and H. T. Nguyen and Vicky Nicolas and Gw{\'e}naelle Aur{\'e}gan and Indira David and Alex Dranovsky and Philippe Hantraye and Ren{\'e} Hen and A. M. Gardier and Nicole D{\'e}glon and Bruno P. Guiard},
  journal={Translational Psychiatry},
  year={2013},
  volume={3}
}
The therapeutic activity of selective serotonin (5-HT) reuptake inhibitors (SSRIs) relies on long-term adaptation at pre- and post-synaptic levels. The sustained administration of SSRIs increases the serotonergic neurotransmission in response to a functional desensitization of the inhibitory 5-HT1A autoreceptor in the dorsal raphe. At nerve terminal such as the hippocampus, the enhancement of 5-HT availability increases brain-derived neurotrophic factor (BDNF) synthesis and signaling, a major… 
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