BDNF modifies hippocampal KCC2 and NKCC1 expression in a temporal lobe epilepsy model.

@article{Eftekhari2014BDNFMH,
  title={BDNF modifies hippocampal KCC2 and NKCC1 expression in a temporal lobe epilepsy model.},
  author={Sanaz Eftekhari and Soraya Mehrabi and Mansooreh Soleimani and Gholamreza Ghassanzadeh Hassanzadeh and Amene Shahrokhi and Hossein Ahari Mostafavi and Parisa Hayat and Mahmood Barati and Hajar Mehdizadeh and Reza Rahmanzadeh and Mahmoud Reza Hadjighassem and Mohammad Taghi Joghataei},
  journal={Acta neurobiologiae experimentalis},
  year={2014},
  volume={74 3},
  pages={276-87}
}
Excitatory GABA actions, induced by altered expression of chloride transporters (KCC2/NKCC1), can contribute to seizure generation in temporal lobe epilepsy. In the present study, we evaluated whether BDNF administration can affect KCC2/NKCC1 expression, ictogenesis and behavioral alterations in this paradigm. Status epilepticus was induced in male rats with pilocarpine, followed by a treatment of either a single high dose or multiple injections of BDNF during the latent phase of temporal lobe… CONTINUE READING