BDNF induces transport of PSD-95 to dendrites through PI3K-AKT signaling after NMDA receptor activation

@article{Yoshii2007BDNFIT,
  title={BDNF induces transport of PSD-95 to dendrites through PI3K-AKT signaling after NMDA receptor activation},
  author={Akira Yoshii and Martha Constantine‐Paton},
  journal={Nature Neuroscience},
  year={2007},
  volume={10},
  pages={702-711}
}
The N-methyl-D-aspartate receptor (NMDAR), brain-derived neurotrophic factor (BDNF), postsynaptic density protein 95 (PSD-95) and phosphatidylinositol 3-kinase (PI3K) have all been implicated in long-term potentiation. Here we show that these molecules are involved in a single pathway for synaptic potentiation. In visual cortical neurons in young rodents, the neurotrophin receptor TrkB is associated with PSD-95. When BDNF is applied to cultured visual cortical neurons, PSD-95–labeled synaptic… 
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TLDR
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TLDR
It is shown using super-resolution imaging, biochemical approaches and in vivo models that the trans-synaptic organizing protein ephrin-B3 controls the synaptic localization and stability of PSD-95 and links these events to changes in neuronal activity via negative regulation of a newly identified mitogen-associated protein kinase (MAPK)-dependent phosphorylation site on ephinus B3, Ser332.
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