BDNF induces translocation of initiation factor 4E to mRNA granules: evidence for a role of synaptic microfilaments and integrins.

@article{Smart2003BDNFIT,
  title={BDNF induces translocation of initiation factor 4E to mRNA granules: evidence for a role of synaptic microfilaments and integrins.},
  author={Fiona M Smart and Gerald M. Edelman and Peter W. Vanderklish},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 24},
  pages={14403-8}
}
In many cell types, translation can be regulated by a redistribution of translation initiation factors to actin-based cytoskeletal compartments that contain bound mRNAs. This process is evoked by extracellular signals and is regulated by determinants of cytoskeletal organization, such as integrins. In the present experiments, we provide evidence that similar mechanisms regulate local translation in dendrites during synaptic plasticity. Treatment of various neuronal preparations with the brain… CONTINUE READING

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Cellular and Molecular Neuroscience Series, ed

  • G. Banker, K. Goslin
  • 1991

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