BDNF-induced LTP in dentate gyrus is impaired with age: analysis of changes in cell signaling events.

@article{Gooney2004BDNFinducedLI,
  title={BDNF-induced LTP in dentate gyrus is impaired with age: analysis of changes in cell signaling events.},
  author={Martina Gooney and ElHoucine Messaoudi and Frank O Maher and Clive R Bramham and Marina A. Lynch},
  journal={Neurobiology of aging},
  year={2004},
  volume={25 10},
  pages={1323-31}
}
Brain-derived neurotrophic factor (BDNF) has emerged as a major regulator of synaptic plasticity in the adult brain and acute BDNF infusion has been shown to trigger long-term potentiation (BDNF-LTP) in adult rats. Here we compared the effects of acute BDNF infusion in young adult and aged anesthetized rats. In young rats, BDNF-LTP was accompanied by increased activation of the BDNF receptor TrkB, and extracellular signal-regulated kinase (ERK), as well as enhanced evoked release of glutamate… CONTINUE READING

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