BDNF increases the early expression of TRH mRNA in fetal TrkB+ hypothalamic neurons in primary culture.

@article{GuerraCrespo2001BDNFIT,
  title={BDNF increases the early expression of TRH mRNA in fetal TrkB+ hypothalamic neurons in primary culture.},
  author={Magdalena Guerra-Crespo and Raimundo Ubieta and Patricia Joseph-Bravo and J. L. Charli and Leonor P{\'e}rez-Mart{\'i}nez},
  journal={The European journal of neuroscience},
  year={2001},
  volume={14 3},
  pages={483-94}
}
Known effects of neurotrophins in the developing central nervous system include induction or regulation of peptide expression. Hypothalamic postmitotic thyrotropin-releasing hormone (TRH)-producing neurons may require neurotrophins for survival and/or differentiation. This issue was investigated using primary cell cultures derived from 17-day-old fetal rat hypothalamus seeded in serum-free medium and analysed up to 4 days in vitro culture. Neurotrophin receptor (TrkB and TrkC) mRNA expression… CONTINUE READING
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