BDNF in Synaptic Plasticity and Memory

  title={BDNF in Synaptic Plasticity and Memory},
  author={N. H. Woo and B. Lu},
  • N. H. Woo, B. Lu
  • Published 2009
  • Psychology
  • A remarkable feature of brain-derived neurotrophic factor (BDNF) is that its cellular processes, including transcription, intracellular trafficking, secretion, proteolytic processing, and receptor signaling, are tightly controlled by neuronal activity. This feature makes BDNF a key secretory protein for synapse-specific modulation in activity-dependent synaptic plasticity. Indeed, cumulative results indicate that mature BDNF facilitates early phase long-term potentiation (E-LTP) in the… CONTINUE READING

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