BDNF in Synaptic Plasticity and Memory

@inproceedings{Woo2009BDNFIS,
  title={BDNF in Synaptic Plasticity and Memory},
  author={Newton H. Woo and Bai Lu},
  year={2009}
}

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References

SHOWING 1-10 OF 16 REFERENCES

Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus

The results suggest that BDNF may regulate LTP in developing and adult hippocampus by enhancing synaptic responses to tetanic stimulation, and a TrkB–IgG fusion protein, which scavenges endogenous BDNF11, reduced the synaptic responses in adult hippocampus as well as the magnitude of LTP.

BDNF and activity-dependent synaptic modulation.

  • B. Lu
  • Biology
    Learning & memory
  • 2003
Several potential mechanisms with which neuronal activity could control the synapse-specificity of neurotrophin regulation are discussed, with particular emphasis on BDNF.

Activation of p75NTR by proBDNF facilitates hippocampal long-term depression

It is reported that proBDNF, by activating p75NTR, facilitates hippocampal long-term depression (LTD) and the finding that mature BDNF promotes synaptic potentiation, suggest a bidirectional regulation of synaptic plasticity by proBD NF and matureBDNF.

Neurotrophins as synaptic modulators

  • M. Poo
  • Biology
    Nature Reviews Neuroscience
  • 2001
By this account, neurotrophins may participate in activity-dependent synaptic plasticity, linking synaptic activity with long-term functional and structural modification of synaptic connections.

Cleavage of proBDNF by tPA/Plasmin Is Essential for Long-Term Hippocampal Plasticity

It is reported that tPA, by activating the extracellular protease plasmin, converts the precursor proBDNF to the mature BDNF (mBDNF), and that such conversion is critical for L-LTP expression in mouse hippocampus.

Sortilin Controls Intracellular Sorting of Brain-Derived Neurotrophic Factor to the Regulated Secretory Pathway

A novel function for a Vps10p domain protein, sortilin, in controlling BDNF sorting to the regulated secretory pathway and a framework, based on divergent presynaptic regulation of sorting to secretory pathways, to explain how two ligands for tropomyosin-related kinase B, BDNF and NT-4, can mediate diverse biological responses are explained.

The yin and yang of neurotrophin action

The proteolytic cleavage of proneurotrophins represents a mechanism that controls the direction of action of neurotrophins and has profound implications for the understanding of the role of neurotrophic molecules in a wide range of cellular processes.